Towards a Unified Model of RAF Inhibitor Resistance
نویسندگان
چکیده
منابع مشابه
Towards a unified model of RAF inhibitor resistance.
ATP-competitive RAF inhibitors elicit profound but often temporary antitumor responses in patients with BRAF-mutant melanoma. Analysis of tumor samples collected at the time of disease progression indicates that alterations within the extracellular signal-regulated kinase (ERK) pathway that result in reactivation of ERK signaling are present in most patients. Mutations in the phosphoinositide 3...
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ژورنال
عنوان ژورنال: Cancer Discovery
سال: 2014
ISSN: 2159-8274,2159-8290
DOI: 10.1158/2159-8290.cd-13-0961